Fig. 1 · Structure
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α-Fluoromethylhistidine dihydrochloride
Histidine Decarboxylase Inhibitor
α-Fluoromethylhistidine dihydrochloride is a potent inhibitor of histidine decarboxylase, significantly depleting histamine levels in enterochromaffin-like (ECL) cells. This compound effectively reduces the number and volume density of secretory vesicles within these cells, while leaving mast cell histamine storage unaffected. It mitigates omeprazole-induced vacuolization of ECL cells and diminishes gastrin-induced histamine efflux. Additionally, α-Fluoromethylhistidine dihydrochloride inhibits both basal and gastrin-stimulated gastric acid secretion, providing valuable insights for research on gastric physiology and related pathologies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 81839-27-2 |
| Applications | Histidine Decarboxylase Inhibitor |
| Formula | C7H12Cl2FN3O2 |
| Molecular Weight | 260.09 |
| SMILES | N[C@](CC1=CNC=N1)(CF)C(O)=O.Cl.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.