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a-Helical Corticotropin Releasing Factor (12-41)

CRF Inhibitor

a-Helical Corticotropin Releasing Factor (12-41) is an α-helical analogue of corticotropin-releasing factor (CRF) that acts as a CRF inhibitor. By mimicking the structure of natural CRF, this peptide effectively suppresses the secretion of adrenocorticotropic hormone (ACTH), providing valuable insights into stress response mechanisms. Its primary applications include studying the neuroendocrine regulation of stress and investigating potential therapeutic strategies for stress-related disorders.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	158535-55-8
Applications	CRF Inhibitor
Formula	C₁₅₂H₂₅₁N₄₃O₄₇S₂
Molecular Weight	3497.01
SMILES	[C@H](CC1=CN=CN1)(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)C)=O)CCC(O)=O)=O)CCC(O)=O)=O)CC(C)C)=O)CC(C)C)=O)CC(C)C)=O)CCCNC(=N)N)=O)CC(N)=O)=O)CC(C)C)=O)C)=O)C)=O)CCC(N)=O)=O)CCC(O)=O)=O)C)=O)CCC(O)=O)=O)CCC(N)=O)=O)CCC(O)=O)=O)C)=O)CCCCN)=O)C)=O)CCSC)=O)CCC(O)=O)=O)CC(C)C)=O)CCSC)=O)CCC(O)=O)=O)CCCNC(=N)N)=O)CC(C)C)=O)CC(C)C)=O)NC([C@H](CC2=CC=CC=C2)N)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.