Fig. 1 · Structure
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A11
ANXA1-EphA2 Interaction Blocker
A11 is a peptide that disrupts the interaction between ANXA1 and EphA2. It effectively reduces ANXA1 binding to EphA2 while promoting increased association of Cbl, an E3 ubiquitin ligase, with EphA2. This results in decreased EphA2 levels and enhanced ubiquitination, leading to increased internalization and colocalization of EphA2 and Cbl in nasopharyngeal carcinoma (NPC) cells. A11 has demonstrated significant inhibition of NPC cell proliferation, migration, invasion, and angiogenesis, making it a valuable tool for cancer research applications targeting EphA2 signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Blocker |
| CAS Number | 2412926-30-6 |
| Applications | ANXA1-EphA2 Interaction Blocker |
| Formula | C117H204N46O32 |
| Molecular Weight | 2767.16 |
| Synonyms | ANXA1-derived 11 amino acid–long peptide |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.