Fig. 1 · Structure
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A12B4C3
hPNKP Inhibitor
A12B4C3 is a potent inhibitor of human polynucleotide kinase/phosphatase (hPNKP) with an IC50 value of 0.06 μM. This compound exhibits significant antiproliferative activity against various cancer cell lines and has the potential to enhance the radiosensitivity of certain tumors. A12B4C3 serves as a valuable tool for researchers studying cancer biology and therapeutic strategies that target DNA repair mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1005129-80-5 |
| Applications | hPNKP Inhibitor |
| Formula | C30H38N4O5 |
| Molecular Weight | 534.65 |
| SMILES | O=C1N(C(C2N(C(C(CCCCCCCCCC)O)C=CC12)NC3=CC=C([N+]([O-])=O)C=C3)=O)C4=CC=CC=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.