A457 is a selective antagonist of the prokineticin receptor PKR2, exhibiting an IC50 value of 102 nM. This compound effectively restores cell surface expression and functionality of the P290S PKR2 variant, while showing no activity against the W178S and G234D PKR2 mutations. A457 is valuable for research applications focused on the modulation of PKR2-related pathways and the study of receptor mutations.
A457 is a selective antagonist of the prokineticin receptor PKR2, exhibiting an IC50 value of 102 nM. This compound effectively restores cell surface expression and functionality of the P290S PKR2 variant, while showing no activity against the W178S and G234D PKR2 mutations. A457 is valuable for research applications focused on the modulation of PKR2-related pathways and the study of receptor mutations.
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