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AA3-DLin

Lipid

AA3-DLin is an ionizable cationic lipid with a pKa of 5.8, primarily used for the delivery of mRNA through lipid nanoparticles (LNPs). This compound has demonstrated strong immunogenicity when utilized in COVID-19 vaccines encapsulating SARS-CoV-2 spike mRNAs, effectively inducing immune responses in BALB/c mouse models. Its applications are significant in the development of mRNA-based therapeutics and vaccines, contributing to advancements in infectious disease research and vaccine technology.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	3027565-91-6
Applications	Lipid
Formula	C₄₄H₇₈N₂O₄
Molecular Weight	699.10
SMILES	CCCCC/C=C\C/C=C\CCCCCCCC(OCCN1CCN(CC1)CCOC(CCCCCCC/C=C\C/C=C\CCCCC)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.