Fig. 1 · Structure
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AACA
Sclerostin Inhibitor
AACA is a potent sclerostin inhibitor that targets the loop 3 region of sclerostin with a binding affinity (Kd) of 15.4 nM. This compound demonstrates significant anti-osteoporotic activity by modulating the Wnt signaling pathway, promoting bone formation and mineralization. AACA is intended for use in research applications focused on understanding bone metabolism and the development of osteoporosis treatments.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2515609-54-6 |
| Applications | Sclerostin Inhibitor |
| Formula | C14H14N2O4 |
| Molecular Weight | 274.27 |
| SMILES | O=C(CNC(C1=CC=C(C=C1)C#CCNC(C)=O)=O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.