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AB-3PRGD2

αvβ3 Radiotherapeutic Agent

AB-3PRGD2 is a radiotherapeutic agent that specifically targets integrin αvβ3. This compound demonstrates enhanced tumor uptake and extended retention within the tumor microenvironment, resulting in significant suppression of tumor growth. Additionally, AB-3PRGD2 has the capacity to modulate the tumor immune microenvironment by upregulating PD-L1 expression and promoting an increase in tumor-infiltrating CD8+ T cells, making it a valuable tool for research in cancer therapy and immunomodulation.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2416165-76-7
Applications	αvβ3 Radiotherapeutic Agent
Formula	C₁₃₇H₂₁₅IN₃₀O₄₅S
Molecular Weight	3161.32
SMILES	OC(CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(N[C@@H](CSC2C(N(CCCCCC(NCCOCCOCCOCCOCCC(N[C@@H](CCC(NCCOCCOCCOCCOCCC(NCCCC[C@@H]3NC([C@@H](CC4=CC=CC=C4)NC([C@H](CC(O)=O)NC(CNC([C@H](CCCNC(N)=N)NC3=O)=O)=O)=O)=O)=O)=O)C(NCCOCCOCCOCCOCCC(NCCCC[C@@H]5NC([C@@H](CC6=CC=CC=C6)NC([C@H](CC(O)=O)NC(CNC([C@H](CCCNC(N)=N)NC5=O)=O)=O)=O)=O)=O)=O)=O)=O)C(C2)=O)=O)C(N[C@H](CCCCNC(CCCC7=CC=C(I)C=C7)=O)C(O)=O)=O)=O)CC1)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.