Fig. 1 · Structure
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AB25583
Polθ-hel Inhibitor
AB25583 is a small molecule inhibitor targeting the Polθ helicase with an IC50 of 6 nM. It selectively induces apoptosis in BRCA1/2 deficient cells and enhances the efficacy of Olaparib in cancer cells harboring pathogenic BRCA1/2 mutations. This compound is valuable for research focused on tumor biology and therapeutic approaches for BRCA-deficient cancers.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2565637-94-5 |
| Applications | Polθ-hel Inhibitor |
| Formula | C22H17ClN4O3S |
| Molecular Weight | 452.91 |
| SMILES | ClC1=CC=C(COC2=NN=C(NC(C3=C(C4=CC=CC=C4OC)C=CN=C3)=O)S2)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.