Fig. 1 · Structure
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ABBV-712
TYK2 Inhibitor
ABBV-712 is a selective, orally active inhibitor of Tyrosine kinase 2 (TYK2). With EC50 values of 0.01 μM for TYK2 JH2, 0.19 μM for TYK2 cells, and 0.17 μM for human whole blood, ABBV-712 demonstrates significant potency. This compound exhibits anti-inflammatory activity and is useful in the investigation of autoimmune diseases, making it a valuable tool for researchers exploring TYK2-related pathways and therapeutic interventions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2368945-27-9 |
| Applications | TYK2 Inhibitor |
| Formula | C24H28N4O5 |
| Molecular Weight | 452.50 |
| SMILES | CC(NC1=CC2=C(C=N1)N(C=C2C3=NC([C@]4(COCC4)OC)=CC(COC)=C3)C5COC5)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.