Fig. 1 · Structure
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ABC99
Notum Inhibitor
ABC99 is a selective inhibitor of the Wnt-deacylating enzyme Notum, with an IC50 value of 13 nM. By inhibiting Notum, ABC99 effectively preserves Wnt3A signaling, making it a valuable tool for studying Wnt pathway modulation. This compound is suitable for research applications focused on developmental biology, cancer research, and stem cell differentiation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2331255-53-7 |
| Applications | Notum Inhibitor |
| Formula | C22H21ClN4O5 |
| Molecular Weight | 456.88 |
| SMILES | O=C(N1C2=CC=CC=C2OCC1)ON(C3=O)C(N4C3CN(CC5=CC=C(Cl)C=C5)CC4)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.