Fig. 1 · Structure
Documents & Downloads
ABCG2-IN-1
ABCG2 Inhibitor
ABCG2-IN-1 is a potent inhibitor of the ABCG2 transporter, exhibiting an IC50 value of 0.13 μM. This compound, a Ko143 analog, demonstrates favorable oral pharmacokinetics in murine models, making it suitable for in vivo studies. ABCG2-IN-1 is valuable for research exploring drug transport mechanisms, multidrug resistance, and potential therapeutic applications against cancers that exploit ABCG2-mediated efflux.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2559759-40-7 |
| Applications | ABCG2 Inhibitor |
| Formula | C26H36N4O4 |
| Molecular Weight | 468.59 |
| SMILES | CC(C)C[C@H]1C2=C(C[C@]3([H])N1C([C@@H](NC3=O)CCC(NC(C)(C)C)=O)=O)C4=CC=C(OC)C=C4N2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.