Fig. 1 · Structure
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ABCG2-IN-3
ABCG2 Inhibitor
ABCG2-IN-3 is a selective inhibitor of the breast cancer resistance protein ABCG2, demonstrating an IC50 of 0.238 µM. This compound effectively reverses ABCG2-mediated resistance to SN-38 and inhibits ABCG2's ATPase activity. ABCG2-IN-3 is valuable for research applications investigating multidrug resistance in cancer therapy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1942919-63-2 |
| Applications | ABCG2 Inhibitor |
| Formula | C25H20Cl2N2O2 |
| Molecular Weight | 451.34 |
| SMILES | COC1=CC=C(C=C1)C(N2C(C3=C(CC2)C(C=CC=C4)=C4N3)C5=CC(Cl)=C(C=C5)Cl)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.