Fig. 1 · Structure
Documents & Downloads
Abemaciclib metabolite M18
CDK4/6 Inhibitor
Abemaciclib metabolite M18 is a potent inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6), key regulators of the cell cycle. This compound exhibits significant antitumor activity and has been utilized in the formulation of PROTAC-based degraders targeting CDK4/6 alongside a CRBN ligand. Its application in cancer research highlights its potential for therapeutic development in various malignancies.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2704316-81-2 |
| Applications | CDK4/6 Inhibitor |
| Formula | C25H28F2N8O |
| Molecular Weight | 494.54 |
| Synonyms | LSN3106729 |
| SMILES | FC(C=N1)=C(C2=CC(N(C(C)C)C(CO)=N3)=C3C(F)=C2)N=C1NC4=NC=C(C=C4)CN5CCNCC5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.