Fig. 1 · Structure
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ABP688
human mGluR5 antagonist
ABP688 is a potent antagonist of the human metabotropic glutamate receptor 5 (mGluR5), with a binding affinity (Ki) of 1.7 nM. This compound serves as a valuable tool in elucidating the role of mGluR5 in various neurological disorders. Additionally, radioisotope-labeled ABP688 can be utilized as a PET tracer for in vivo imaging studies, aiding in the investigation of receptor dynamics and distribution in clinical settings.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 924298-51-1 |
| Applications | human mGluR5 antagonist |
| Formula | C15H16N2O |
| Molecular Weight | 240.30 |
| SMILES | CC1=NC(C#CC2=C/C(CCC2)=N/OC)=CC=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.