Fig. 1 · Structure
Documents & Downloads
ABT-288
H3R Antagonist
ABT-288 is a potent and selective antagonist of the histamine H3 receptor (H3R), demonstrating competitive inhibition with Ki values of 1.9 nM for human and 8.2 nM for rat H3Rs. This compound is valuable for investigating cognitive impairment and associated pathways, facilitating research into neurological disorders. Its specificity for H3R makes it a useful tool for studying the role of histamine signaling in cognitive function.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 948845-91-8 |
| Applications | H3R Antagonist |
| Formula | C23H24N4O |
| Molecular Weight | 372.46 |
| SMILES | CN1C[C@]2([H])N(C3=CC=C(C4=CC=C(N5C(C=CC=N5)=O)C=C4)C=C3)CC[C@]2([H])C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.