Fig. 1 · Structure

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ABT-670

dopamine D4 receptor agonist

ABT-670 is a selective, oral bioavailable agonist of dopamine D4 receptor, with EC50 of 89 nM, 160 nM, and 93 nM for human?D4, ferret?D4, and rat D4, respectively.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
HEK293 EC50 160 nM Agonist activity at ferret D4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPR [PMID: 17149874]
HEK293 EC50 89 nM Agonist activity at human D4.4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPR [PMID: 17149874]
HEK293 EC50 93 nM Agonist activity at rat D4 receptor in HEK293 cells coexpressing G-alpha-qo5 by FLIPR [PMID: 17149874]

Specifications

Manufacturer Adooq Bioscience
Actions Agonist
CAS Number 630119-43-6
Applications dopamine D4 receptor agonist
Formula C19H23N3O2
Molecular Weight 325.4
SMILES
O=C(NCN1CCC(C2=CC=CC=[N+]2[O-])CC1)C3=CC=CC(C)=C3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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