ABT-724 is a potent and highly selective agonist of the dopamine D4 receptor, exhibiting an EC50 of 12.4 nM for the human receptor. It also demonstrates efficacy as a partial agonist at the rat and ferret D4 receptors, with EC50 values of 14.3 nM and 23.2 nM, respectively. ABT-724 shows minimal activity against dopamine D1, D2, D3, and D5 receptors, making it a valuable tool for exploring the role of the D4 receptor in neurological conditions and potential therapeutic applications for erectile dysfunction.
ABT-724 is a potent and highly selective agonist of the dopamine D4 receptor, exhibiting an EC50 of 12.4 nM for the human receptor. It also demonstrates efficacy as a partial agonist at the rat and ferret D4 receptors, with EC50 values of 14.3 nM and 23.2 nM, respectively. ABT-724 shows minimal activity against dopamine D1, D2, D3, and D5 receptors, making it a valuable tool for exploring the role of the D4 receptor in neurological conditions and potential therapeutic applications for erectile dysfunction.
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