Fig. 1 · Structure
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ABT-866
Adrenoceptor Modulator
ABT-866 is a selective α1A-adrenoceptor agonist and antagonist for the α1B- and α1D-adrenoceptor subtypes. It demonstrates an EC50 of 0.60 μM at the α1A receptor in rabbit urethra tissue and exhibits pA2 values of 5.4 and 6.2 at the α1B and α1D receptors in rat spleen and aorta, respectively. ABT-866 shows promising urethral selectivity with reduced cardiovascular side effects, making it a valuable tool for studying stress urinary incontinence and related disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 258526-74-8 |
| Applications | Adrenoceptor Modulator |
| Formula | C12H15N3O2S |
| Molecular Weight | 265.33 |
| SMILES | O=S(NC1=CC=CC(CC2=CN=CN2)=C1)(CC)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.