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Fig. 1 · Structure
Cat. No.
A14741
CAS No.
480-44-4
Formula
C16H12O5
Mol. Weight
284.26

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Acacetin

Acacetin is a flavonoid with anti-peroxidative and anti-inflammatory properties.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
A549 IC50 0.4 μg/mL Cytotoxicity against human A549 cells by SRB assay [PMID: 31784199]
HCT-15 IC50 0.4 μg/mL Cytotoxicity against human HCT15 cells by SRB assay [PMID: 31784199]
MOLM-13 IC50 9.1 μM Cytotoxicity against human MOLM-13 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay [PMID: 33393294]
Monocyte IC50 22 μM Inhibition of TNFalpha expression in LPS-stimulated human monocytes treated 30 mins before LPS challenge measured after 14 hrs by ELISA [PMID: 10096854]
MV4-11 IC50 6.8 μM Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability measured after 72 hrs by MTT assay [PMID: 33393294]
Neutrophil IC50 7 μM Inhibition of oxidative burst in PMA-stimulated human neutrophils assessed as inhibition of superoxide anion radical-induced lucigenin oxidation incubated for 5 mins prior to PMA challenge by chemiluminescence assay [PMID: 23871908]
RAW264.7 IC50 27.7 μM Inhibition of LPS-stimulated nitric oxide production in mouse RAW264.7 cells by Greiss method [PMID: 27955927]
RAW264.7 IC50 5.9 μM Inhibition of LPS induced NO production in mouse RAW264.7 cells measured after 24 hrs by Griess reagent based assay [PMID: 33667099]
RAW264.7 IC50 53.7 μM Inhibition of LPS/INF-gamma-stimulated nitric oxide production in mouse RAW264.7 cells by Greiss method [PMID: 27955927]
RAW264.7 IC50 6.2 μM Antiinflammatory activity against LPS-stimulated mouse RAW264.7 cells assessed as decrease in PGE2 production preincubated for 1 hr followed by LPS stimulation and measured after 24 hrs by ELISA [PMID: 31747281]
RAW264.7 CC50 60.9 μM Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability measured after 24 hrs by MTT assay [PMID: 33667099]
SK-MEL-2 IC50 0.4 μg/mL Cytotoxicity against human SK-MEL-2 cells by SRB assay [PMID: 31784199]
SK-OV-3 IC50 0.4 μg/mL Cytotoxicity against human SKOV3 cells by SRB assay [PMID: 31784199]
XF498 IC50 0.4 μg/mL Cytotoxicity against human XF498 cells by SRB assay [PMID: 31784199]

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Specifications

Manufacturer Adooq Bioscience
CAS Number 480-44-4
Formula C16H12O5
Molecular Weight 284.26
Synonyms Linarigenin
SMILES
COC1=CC=C(C=C1)C2=CC(=O)C3=C(C=C(C=C3O2)O)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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