Fig. 1 · Structure
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ACBI-4
KRAS(on) PROTAC Degrader
ACBI-4 is a selective PROTAC degrader targeting the active state of KRAS (KRAS(on)). This compound exhibits significant anti-proliferative effects and effectively degrades various KRAS mutants, including KRASG12R, in cancer cell models. ACBI-4 is valuable for research applications focused on understanding KRAS-mediated signaling pathways and developing targeted cancer therapies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 3097985-19-5 |
| Applications | KRAS(on) PROTAC Degrader |
| Formula | C50H63N15O4S |
| Molecular Weight | 970.20 |
| SMILES | CC([C@H](N1N=NC2=C1CC[C@H](CCCN3C[C@@H](N(CCC3)C4=NC(C5=NOC([C@@]6(C7=C(CCC6)SC(N)=C7C#N)C)=N5)=CC=N4)C)C2)C(N8C[C@@H](C[C@H]8C(NCC9=CC=C%10C(N(N=C%10)C)=C9)=O)O)=O)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.