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Biological Activity
Acenocoumarol is a coumarin that is used as an anticoagulant. Its actions and uses are similar to those of Warfarin. As a vitamin K antagonist, acenocoumarol inhibits vitamin K epoxide reductase, thereby inhibiting the reduction of vitamin K and the availability of vitamin KH2. This prevents gamma carboxylation of glutamic acid residues near the N-terminals of the vitamin K-dependent clotting factors, including factor II, VII, IX, and X and anticoagulant proteins C and S. This prevents their activity, preventing thrombin formation.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 28.3 mL | 141.51 mL | 283.02 mL |
| 0.5 mM | 5.66 mL | 28.3 mL | 56.6 mL |
| 1 mM | 2.83 mL | 14.15 mL | 28.3 mL |
| 5 mM | 0.57 mL | 2.83 mL | 5.66 mL |
*The above data is based on the productmolecular weight 353.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A18260 |
|---|---|
| CAS No. | 152-72-7 |
| Formula | C19H15NO6 |
| M. Wt | 353.33 |
| Purity | >98% |
| Synonyms | Sintrom, Acenocoumarin, Nicoumalone, G-23350, Sinthrome |
| SMILES | CC(=O)CC(C1=CC=C(C=C1)[N+]([O-])=O)C1=C(O)C2=CC=CC=C2OC1=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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