Fig. 1 · Structure
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Acetoacetic acid
Oxidative Stress Inducer
Acetoacetic acid is an oxidative stress inducer that primarily targets the antioxidant enzyme system and lipoprotein metabolism. It decreases the mRNA expression and activity of key enzymes such as superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), while increasing malondialdehyde (MDA) levels. Additionally, it inhibits very low-density lipoprotein (VLDL) assembly by downregulating apolipoprotein B100, apolipoprotein E, and low-density lipoprotein receptor (LDLR), leading to triglyceride accumulation in hepatocytes. This compound is valuable for researching metabolic disease mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inducer |
| CAS Number | 541-50-4 |
| Applications | Oxidative Stress Inducer |
| Formula | C4H6O3 |
| Molecular Weight | 102.09 |
| SMILES | CC(CC(O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.