Fig. 1 · Structure
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ACLY-IN-2
hACLY Inhibitor
ACLY-IN-2 is a potent inhibitor of human ATP citrate lyase (hACLY), demonstrating an IC50 of less than 1 nM. This compound is valuable for investigating metabolic disorders, including liver-related diseases and type 2 diabetes, as well as its implications in autoimmunity and cancer research. ACLY-IN-2 serves as a critical tool in the study of pathways involving lipid metabolism and energy homeostasis.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3009136-86-8 |
| Applications | hACLY Inhibitor |
| Formula | C21H14ClF2NO6S |
| Molecular Weight | 481.85 |
| SMILES | O=C(C1=CC2=C(O)C(Cl)=C1)OCCOC3=CC=CC=C3C4=CC(NS2(=O)=O)=C(F)C=C4F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.