Target & Activity
| Target | Activity | Value |
|---|---|---|
| FGFR1 | IC50 | 6 nM |
| VEGFR2 | IC50 | 2 nM |
| Tie-2 | IC50 | 4 nM |
Fig. 1 · Structure
Documents & Downloads
EOC317 (ACTB-1003)
Cat. No.
A14431
CAS
939805-30-8
FGFR1 inhibitor
ACTB-1003 is an oral kinase inhibitor targeting cancer mutations (FGFR inhibition), angiogenesis (inhibition of VEGFR2 and Tie-2) and induces apoptosis (targeting RSK and p70S6K, downstream of PI3 kinase).
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 939805-30-8 |
| Applications | FGFR1 inhibitor |
| Formula | C27H26F5N7O3 |
| Molecular Weight | 591.53 |
| Synonyms | ACTB1003 |
| SMILES | COCC1=C(N2C(=C1C3=CC(=C(C=C3)NC(=O)NC4=C(C=CC(=C4)C(F)(F)F)F)F)C(=NC=N2)N)CN5CCOCC5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.