Fig. 1 · Structure
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Actein
Anticancer Agent
Actein is a triterpene glycoside derived from the rhizomes of Cimicifuga foetida, primarily functioning as an anticancer agent. This compound demonstrates significant antiproliferative effects on cancer cells, particularly in bladder cancer, by inducing autophagy and apoptosis through the activation of reactive oxygen species (ROS) and the c-Jun N-terminal kinase (JNK) pathway while inhibiting the AKT signaling pathway. Actein exhibits low toxicity in vivo, making it a promising candidate for further research in cancer therapeutics.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 18642-44-9 |
| Applications | Anticancer Agent |
| Formula | C37H56O11 |
| Molecular Weight | 676.83 |
| SMILES | C[C@]12[C@@]3([H])[C@@]4(C[C@@H](OC(C)=O)[C@@]1([C@]5([H])[C@](O[C@]6([C@H]7[C@]([C@@H](O)O6)(C)O7)C[C@H]5C)([H])C2)C)[C@@]8([C@@](C(C)([C@@H](O[C@@]9([H])[C@@H]([C@H]([C@H](O)CO9)O)O)CC8)C)([H])CC3)C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.