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AD16

LINE-1 Retrotransposon Endonuclease Inhibitor

AD16 (Acetamide) functions as an inhibitor of LINE-1 retrotransposon endonuclease, exhibiting an IC50 of 4.7 μM. This compound effectively reduces LINE-1 retrotransposition, minimizing associated DNA damage and inflammation, particularly in senescent cells. AD16 is valuable for research applications aimed at understanding the roles of retrotransposons in genomic stability and age-related cellular processes.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	311315-04-5
Applications	LINE-1 Retrotransposon Endonuclease Inhibitor
Formula	C₂₄H₂₀N₁₄O₃S₂
Molecular Weight	616.64
SMILES	NN1C=NN2C(SCC(CC3=CC=C(C=C3)C4=NC5=CC(NC(CSC6=NN=C7N(C=NN67)N)=O)=CC=C5O4)=O)=NN=C12

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.