Fig. 1 · Structure
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AD4
PCLAF Inhibitor
AD4 is a proteolytic targeting chimera (PROTAC) designed to inhibit PCLAF. This compound effectively degrades PCLAF in RS4;11 cells with an IC50 of 0.6 nM, leading to the activation of the p21/Rb pathway and demonstrating anti-tumor effects. In vivo studies have shown that AD4 prolongs survival in RS4;11-transplanted NOD/SCID mice, highlighting its potential for cancer research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 2918262-09-4 |
| Applications | PCLAF Inhibitor |
| Formula | C55H78N4O15 |
| Molecular Weight | 1035.23 |
| SMILES | C[C@@H]1[C@@]2([H])[C@]34[C@@](O[C@@H]1OCCN(C(CCCCCCCNC5=C6C(C(N(C7C(NC(CC7)=O)=O)C6=O)=O)=CC=C5)=O)CCO[C@H]8O[C@@]9([H])[C@]%10%11[C@](CC[C@H]([C@]%10([H])CC[C@](O9)(OO%11)C)C)([H])[C@H]8C)([H])O[C@](OO3)(CC[C@@]4([H])[C@@H](CC2)C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.