Fig. 1 · Structure
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ADAMTS-5-IN-2
ADAMTS-5/BoNT/A LC Inhibitor
ADAMTS-5-IN-2 is an inhibitor of ADAMTS-5 and botulinum neurotoxin A light chain (BoNT/A LC), with IC50 values of 9.6 μM and 0.71 μM respectively. This compound serves as a valuable tool in research concerning osteoarthritis, botulism, and other related pathologies. Its ability to selectively inhibit these targets makes it suitable for investigating therapeutic strategies in diseases associated with extracellular matrix degradation and neurotoxic disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 294648-66-1 |
| Applications | ADAMTS-5/BoNT/A LC Inhibitor |
| Formula | C17H15N3OS |
| Molecular Weight | 309.39 |
| SMILES | O=C1NC2=C(C=C(CC)C=C2)C13SC(C4=CC=CC=C4)=NN3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.