Fig. 1 · Structure
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ADAMTS-5-IN-3
ADAMTS-5/4 Inhibitor
ADAMTS-5-IN-3 is a potent inhibitor of the metalloproteinases ADAMTS-5 and ADAMTS-4, exhibiting IC50 values of 8 nM and 12 nM, respectively. This compound is relevant in the study of diseases characterized by cartilage degradation and disruptions in cartilage homeostasis, such as osteoarthritis and rheumatoid arthritis. Researchers can utilize ADAMTS-5-IN-3 to investigate potential therapeutic strategies aimed at modulating the activity of these enzymes in various pathological conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2688733-96-0 |
| Applications | ADAMTS-5/4 Inhibitor |
| Formula | C20H23Cl2N3O3 |
| Molecular Weight | 424.32 |
| SMILES | O=C(N1C[C@@H](C2=CC(Cl)=C(Cl)C=C2CC1)C)CC[C@]3(C4CC4)C(NC(N3)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.