Fig. 1 · Structure
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ADAMTS-5 Inhibitor
ADAMTS-5 Inhibitor
ADAMTS-5 Inhibitor is a potent inhibitor of ADAMTS-5 (aggrecanase-2), exhibiting an IC50 of 1.1 µM. This compound demonstrates greater than 40-fold selectivity over ADAMTS-4 (aggrecanase-1). It is utilized in research applications focused on cartilage degradation, osteoarthritis, and the role of aggrecanases in extracellular matrix remodeling.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 929634-33-3 |
| Applications | ADAMTS-5 Inhibitor |
| Formula | C16H11ClF3N3OS3 |
| Molecular Weight | 449.92 |
| SMILES | O=C1NC(S/C1=C\C2=C(SCC3=CC=C(Cl)C=C3)N(C)N=C2C(F)(F)F)=S |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.