Adapalene-d3 is a deuterium-labeled form of the third-generation synthetic retinoid, Adapalene. This compound acts as a potent retinoic acid receptor (RAR) agonist, demonstrating AC50 values of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, and RARα, respectively. Additionally, Adapalene-d3 inhibits the enzymatic activity of glutamate oxaloacetate transaminase 1 (GOT1) in a non-competitive manner and possesses anti-tumor activity. This reagent is useful for studying acne mechanisms as well as RAR-related biological pathways in research applications.
Adapalene-d3 is a deuterium-labeled form of the third-generation synthetic retinoid, Adapalene. This compound acts as a potent retinoic acid receptor (RAR) agonist, demonstrating AC50 values of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, and RARα, respectively. Additionally, Adapalene-d3 inhibits the enzymatic activity of glutamate oxaloacetate transaminase 1 (GOT1) in a non-competitive manner and possesses anti-tumor activity. This reagent is useful for studying acne mechanisms as well as RAR-related biological pathways in research applications.
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