Adatanserin is a selective partial agonist of the 5-HT1A receptor, exhibiting a high affinity with a Ki value of 1 nM. Additionally, it acts as a moderate-affinity antagonist at the 5-HT2 receptor with a Ki of 73 nM. This compound demonstrates pronounced anxiolytic and antidepressant effects in preclinical animal models, making it a valuable tool for research in anxiety and mood disorders.
Adatanserin is a selective partial agonist of the 5-HT1A receptor, exhibiting a high affinity with a Ki value of 1 nM. Additionally, it acts as a moderate-affinity antagonist at the 5-HT2 receptor with a Ki of 73 nM. This compound demonstrates pronounced anxiolytic and antidepressant effects in preclinical animal models, making it a valuable tool for research in anxiety and mood disorders.
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