Documents & Downloads

Adavosertib acid

Derivative of AZD1775

Adavosertib acid is a derivative of AZD1775, a selective inhibitor of the checkpoint kinases Chk1 and Chk2. This compound is primarily utilized in the synthesis of PROTACs (proteolysis-targeting chimeras), which have become a powerful approach for targeted protein degradation in cancer research. Its role in modulating the cell cycle and enhancing the efficacy of chemotherapy makes it a valuable tool for studies focused on cell proliferation and survival mechanisms.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2714511-66-5
Applications	Derivative of AZD1775
Formula	C₂₈H₃₂N₈O₄
Molecular Weight	544.60
Synonyms	AZD1775 acid; MK-1775 acid
SMILES	O=C(CN1CCN(CC1)C2=CC=C(NC3=NC=C4C(N(CC=C)N(C4=N3)C5=CC=CC(C(C)(C)O)=N5)=O)C=C2)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.