Fig. 1 · Structure
Documents & Downloads
Aderbasib
ADAM10/17 Inhibitor
Aderbasib is a selective inhibitor of ADAM10 and ADAM17, designed for targeted intervention in cancer research. This orally bioavailable hydroxamate compound displays significant antineoplastic activity, making it suitable for investigating various malignancies, including diffuse large B-cell non-Hodgkin lymphoma, HER2+ breast cancer, and gliomas. Its potent inhibitory effects enable detailed studies into the role of ADAM proteases in tumor biology and therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 791828-58-5 |
| Applications | ADAM10/17 Inhibitor |
| Formula | C21H28N4O5 |
| Molecular Weight | 416.47 |
| Synonyms | INCB007839; INCB7839 |
| SMILES | O=C(N(CC1)CCN1C2=CC=CC=C2)[C@H]([C@H](C3)C(NO)=O)N(CC43CC4)C(OC)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.