Fig. 1 · Structure
Documents & Downloads
ADH-6 TFA
Anti-cancer Agent
ADH-6 TFA is a tripyridylamide compound that functions as an anti-cancer agent. It effectively disrupts the self-assembly of the aggregation-nucleating subdomain of mutant p53 DNA-binding domain (DBD), leading to the dissociation of mutant p53 aggregates in human cancer cells. This restoration of p53's transcriptional activity facilitates cell cycle arrest and induces apoptosis, making ADH-6 TFA a valuable tool for cancer research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2990065-87-5 |
| Applications | Anti-cancer Agent |
| Formula | C31H37F3N8O11 |
| Molecular Weight | 754.67 |
| SMILES | O=C(C1=NC(OCCCN)=C(NC(C2=NC(OCCCN)=C(NC(C3=NC(OCCCC)=C([N+]([O-])=O)C=C3)=O)C=C2)=O)C=C1)OC.OC(C(F)(F)F)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.