Fig. 1 · Structure
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ADRA1D receptor antagonist 1 free base
α1D-AR Antagonist
ADRA1D receptor antagonist 1 free base is a potent and selective antagonist of the human α1D-adrenoceptor (α1D-AR), exhibiting a Ki value of 1.6 nM. This compound effectively inhibits bladder contraction in a dose-dependent manner, with an IC30 value of 15 nM. It is suitable for research applications targeting overactive bladder disorders, including urinary urgency, frequency, and incontinence.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1191908-24-3 |
| Applications | α1D-AR Antagonist |
| Formula | C15H13ClN4O |
| Molecular Weight | 300.74 |
| SMILES | O=C(C1=CC(Cl)=CN([C@@H](C2=CC=CC(C#N)=C2)C)C1=N)N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.