ADT-1004 is an orally active prodrug of the pan-RAS inhibitor ADT-007, which is characterized by its reversible, high potency and selectivity. By binding to the nucleotide-free conformation of RAS proteins, ADT-007 effectively inhibits GTP activation, subsequently blocking downstream MAPK and AKT signaling pathways. ADT-1004 is primarily utilized in research focused on pancreatic ductal adenocarcinoma, providing a valuable tool for the investigation of RAS-mediated oncogenic processes.
ADT-1004 is an orally active prodrug of the pan-RAS inhibitor ADT-007, which is characterized by its reversible, high potency and selectivity. By binding to the nucleotide-free conformation of RAS proteins, ADT-007 effectively inhibits GTP activation, subsequently blocking downstream MAPK and AKT signaling pathways. ADT-1004 is primarily utilized in research focused on pancreatic ductal adenocarcinoma, providing a valuable tool for the investigation of RAS-mediated oncogenic processes.
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