Fig. 1 · Structure
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Advantame free acid
Sweetener
Advantame free acid is an N-substituted derivative of aspartame that functions as a high-intensity, low-calorie sweetener. It demonstrates significant interactions with plasma proteins and has the potential to induce hypotension and inhibit the hERG K+ channel, leading to cardiotoxicity. Additionally, Advantame binds to the T1R2/T1R3 taste GPCR, engaging in biased heteromer complex formation with NMBR, which activates sialidase activity in vitro. In prenatal developmental toxicity studies in rabbits, Advantame exhibited maternal toxicity characterized by gastrointestinal disturbances.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 245650-17-3 |
| Applications | Sweetener |
| Formula | C24H30N2O7 |
| Molecular Weight | 458.50 |
| SMILES | OC1=C(OC)C=CC(CCCN[C@@H](CC(O)=O)C(N[C@H](C(OC)=O)CC2=CC=CC=C2)=O)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.