Fig. 1 · Structure
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Advantame
Sweetener
Advantame is an N-substituted derivative of aspartame that primarily functions as a high-intensity, low-calorie sweetener. This compound interacts with plasma proteins and has been shown to potentially induce hypotension and inhibit the hERG K+ channel, raising concerns for cardiotoxicity. Advantame activates the T1R2/T1R3 taste G protein-coupled receptor (GPCR), promoting oligomeric functional selectivity and enhancing sialidase activity in vitro. Additionally, in prenatal developmental toxicity studies on rabbits, Advantame has displayed maternal toxicity characterized by gastrointestinal disturbances.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 714229-20-6 |
| Applications | Sweetener |
| Formula | C24H32N2O8 |
| Molecular Weight | 476.52 |
| SMILES | OC1=C(OC)C=CC(CCCN[C@@H](CC(O)=O)C(N[C@H](C(OC)=O)CC2=CC=CC=C2)=O)=C1.O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.