Fig. 1 · Structure
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ADX-10061
Dopamine D1 Antagonist
ADX-10061 is a potent dopamine D1 receptor antagonist exhibiting a Ki value of 9.1 nM for adenylyl cyclase and 5.8 nM for the D1 receptor, alongside much higher Ki values for D2 and 5-HT2 receptors. This selective inhibition allows for targeted investigations into dopamine-related pathways. ADX-10061 is a valuable tool for studies of schizophrenia and other neuropsychiatric disorders, facilitating the exploration of the therapeutic potential of dopamine modulation in various research contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 128022-68-4 |
| Applications | Dopamine D1 Antagonist |
| Formula | C19H20N2O4 |
| Molecular Weight | 340.37 |
| Synonyms | CEE 03-310; NNC 687 |
| SMILES | OC1=C([N+]([O-])=O)C=C2CCN(C)C[C@H](C3=C(OCC4)C4=CC=C3)C2=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.