Fig. 1 · Structure
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AEG40826
IAP Inhibitor
AEG40826 is a potent inhibitor of apoptosis (IAP) that functions as a second mitochondria-derived activator of caspases (SMAC) mimetic. It effectively degrades cellular inhibitor of apoptosis protein 1 (cIAP1) and interferes with tumor necrosis factor alpha (TNF-α) pro-survival signaling pathways. AEG40826 is widely utilized in cancer research, particularly in studies exploring apoptosis modulation and therapeutic resistance mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 949963-04-6 |
| Applications | IAP Inhibitor |
| Formula | C58H80N10O8 |
| Molecular Weight | 1045.32 |
| Synonyms | HGS1029 |
| SMILES | CN[C@@H](C)C(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@@H](C1)NC(C2=CC=C(C=C2)C(N[C@@H]3CN([C@@H](C3)C(N[C@H]4C5=CC=CC=C5CCC4)=O)C([C@H](C(C)(C)C)NC([C@H](C)NC)=O)=O)=O)=O)C(N[C@H]6C7=CC=CC=C7CCC6)=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.