Fig. 1 · Structure
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AEP-IN-3
AEP Inhibitor
AEP-IN-3 is a potent asparagine endopeptidase (AEP) inhibitor with an IC50 value of 7.8 ± 0.9 nM, demonstrating effective oral bioavailability and the ability to penetrate the blood-brain barrier. This compound is particularly relevant for research into Alzheimer's Disease (AD), where AEP's role in protein aggregation and neurodegeneration may provide insights into disease mechanisms and therapeutic strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2978521-26-3 |
| Applications | AEP Inhibitor |
| Formula | C21H21F4N3O4 |
| Molecular Weight | 455.40 |
| SMILES | O=C(N1C[C@H](F)C[C@H]1C(N[C@@H](CC(N)=O)C#C)=O)C2(CC2)C3=CC=C(OC(F)(F)F)C=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.