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AF-2785

Catalog No.: A66496
CFTR Blocker
AF-2785 is a potent blocker of the cystic fibrosis transmembrane conductance regulator (CFTR). It effectively inhibits the cAMP-activated chloride current in rat epididymal cells, exhibiting an IC50 of 170.6 μM. This reagent is primarily utilized in research focused on contraceptive mechanisms and related studies.
AF-2785 252025-48-2 CFTR Blocker
Grouped product items
Size Price Stock Qty
25mg
$1,405.00
In stock
50mg
$1,790.00
In stock
100mg
$2,240.00
In stock
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Research use only. We do not sell to patients.
Data Sheet SDS

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionAF-2785 is a potent blocker of the cystic fibrosis transmembrane conductance regulator (CFTR). It effectively inhibits the cAMP-activated chloride current in rat epididymal cells, exhibiting an IC50 of 170.6 μM. This reagent is primarily utilized in research focused on contraceptive mechanisms and related studies.
Product Information
Catalog NumA66496
FormulaC17H12Cl2N2O2
Molecular Weight347.20
CAS Number252025-48-2
SMILESO=C(O)/C=C\C1=NN(CC2=C(Cl)C=C(Cl)C=C2)C3=CC=CC=C31
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This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Membrane Transporters-Ion Channels > CFTR