Fig. 1 · Structure
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Afegostat hydrochloride
Active Compound
Afegostat hydrochloride, a potent β-galactosidase inhibitor, primarily targets β-galactosidase to ameliorate conditions associated with GM1-gangliosidosis and Morquio B disease. This compound has been shown to induce the maturation of mutant β-galactosidase in fibroblasts derived from patients with GM1-gangliosidosis. Additionally, Afegostat hydrochloride promotes the reduction of keratin sulfate and oligosaccharide accumulation in patient cells, making it a valuable reagent for research into lysosomal storage disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 161302-93-8 |
| Applications | Active Compound |
| Formula | C6H14ClNO3 |
| Molecular Weight | 183.63 |
| Synonyms | D-Isofagomine hydrochloride; Isofagomine hydrochloride |
| SMILES | OC[C@@H]1[C@H]([C@@H](CNC1)O)O.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.