Fig. 1 · Structure
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Aficamten
Cardiac Myosin Inhibitor
Aficamten (CK-274) is a potent inhibitor of cardiac myosin, exhibiting an IC50 of 1.4 μM. It is primarily utilized in research focused on hypertrophic cardiomyopathy (HCM), providing valuable insights into cardiac muscle function and potential therapeutic strategies. Aficamten's ability to modulate myosin activity makes it a critical tool for exploring the molecular mechanisms underlying heart muscle disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2364554-48-1 |
| Applications | Cardiac Myosin Inhibitor |
| Formula | C18H19N5O2 |
| Molecular Weight | 337.38 |
| Synonyms | CK-274; CK-3773274 |
| SMILES | O=C(C1=CN(C)N=C1)N[C@H]2C3=CC=C(C4=NOC(CC)=N4)C=C3CC2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.