AG-12275

Catalog No.: A54360
CDK Inhibitor
AG-12275 is a selective cyclin-dependent kinase (CDK) inhibitor that targets CDK2 and CDK5. It exhibits potent inhibition of cancer cell proliferation by disrupting the cell cycle progression. This compound is valuable for investigating the roles of CDKs in cancer biology and the development of novel therapeutic strategies targeting these pathways.
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5mg
10mg
50mg
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Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionAG-12275 is a selective cyclin-dependent kinase (CDK) inhibitor that targets CDK2 and CDK5. It exhibits potent inhibition of cancer cell proliferation by disrupting the cell cycle progression. This compound is valuable for investigating the roles of CDKs in cancer biology and the development of novel therapeutic strategies targeting these pathways.
Product Information
Catalog NumA54360
FormulaC21H21F2N5OS
Molecular Weight429.49
CAS Number223784-70-1
SMILESO=C(C1=C(N)N=C(NC2=CC=C(N3CCN(C)CC3)C=C2)S1)C4=C(F)C=CC=C4F
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