Fig. 1 · Structure
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AG 1406
HER2 Inhibitor
AG 1406 is a potent HER2 inhibitor, exhibiting an IC50 of 10.57 μM against the HER2 receptor in BT474 cells, while demonstrating minimal activity against EGFR with an IC50 greater than 50 μM in EGF-3T3 cells. This compound serves as a valuable tool for research focused on HER2-positive cancer models and therapeutic strategies targeting HER2 pathways. AG 1406 is suitable for studies investigating the role of HER2 in tumor progression and resistance mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 71308-34-4 |
| Applications | HER2 Inhibitor |
| Formula | C16H18N2O |
| Molecular Weight | 254.33 |
| SMILES | N#C/C(C#N)=C/C1=CC(C(C)C)=C(O)C(C(C)C)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.