AGH-107 is a highly selective agonist of the 5-HT7 receptor, demonstrating a Ki of 6 nM and an EC50 of 19 nM. It exhibits considerable brain penetration, along with high selectivity for the 5-HT7 receptor over related CNS targets. AGH-107 has also been shown to possess high metabolic stability and low toxicity in HEK-293 and HepG2 cell cultures, making it a valuable tool for studying serotonergic signaling and its implications in neuropsychiatric disorders.
AGH-107 is a highly selective agonist of the 5-HT7 receptor, demonstrating a Ki of 6 nM and an EC50 of 19 nM. It exhibits considerable brain penetration, along with high selectivity for the 5-HT7 receptor over related CNS targets. AGH-107 has also been shown to possess high metabolic stability and low toxicity in HEK-293 and HepG2 cell cultures, making it a valuable tool for studying serotonergic signaling and its implications in neuropsychiatric disorders.
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