Fig. 1 · Structure
Documents & Downloads
AGI-41998
MAT2A Inhibitor
AGI-41998 is a selective inhibitor of methionine adenosyltransferase 2A (MAT2A) that displays potent inhibitory activity with an IC50 of 22 nM in HCT-116 MTAP-null cells. This compound effectively crosses the blood-brain barrier and demonstrates the ability to inhibit S-adenosyl methionine (SAM) synthesis, with an IC50 of 34 nM. AGI-41998 is valuable for studying SAM regulation in the central nervous system (CNS) as well as for investigating its role in the proliferation of colon cancer cells and tumor growth.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2377492-26-5 |
| Applications | MAT2A Inhibitor |
| Formula | C22H16BrF3N4O2 |
| Molecular Weight | 505.29 |
| SMILES | O=C1C(C2=CC=C(Br)C=C2)=C3N=C(NCC(F)(F)F)N=CC3=CN1C4=CC=C(OC)C=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.